I am on batocera 5.22 X86_64 version and I have an AMD Ryzen CPU. I experience issues as well.
About game does not lauch (select game -> try to launch -> come back to games selection list) :
Sega CD
PC Engine CD
PS2
MSX
Lynx
FDS
Dreamcast
Colecovision
Atari ST
About game does lauch but doesn't start (select game -> emulator launch -> game does not start, black screen) :
3DO
Atari 5200
Do you think it is BIOS related ? I know that games on PS2 does work on my Retropie setup in the same configuration, but not on Batocera 5.22.
Thank you.