Was on 5.21 before. Nothing works from most systems, SNES, Genesis, Gameboy, MAME, FBA, SegaCD,
The systems that I tested either have the correct BIOS (I checked under Missing BIOS option), or they dont require one.
My biggest issue would be that I format the drive and start from scratch again, because I have no place to store everything on this drive before doing that.
UPDATE: I think it's everything that uses LIBRETRO was affected. Everything that does work has it's own emulator. DOSBOX, CITRA, REICAST, DOLPHIN, PPSSPP, and SCUMMVM. I even went to my Commodore64 settings and changed that emulator to VICE instead of LIBRETRO and now it loaded.